A comprehensive review on the pancreatic lipase inhibitory peptides: A future anti-obesity strategy
Tan Yong Chia 1 * , Chee-Yuen Gan 1 * , Muhammad Hakimin Shafie 1 , Pei Gee Yap 1 , Ainolsyakira Mohd Rodhi 1 , Ashfaq Ahmad 2 , Vikneswaran Murugaiyah 3 4 , Mohammed H Abdulla 5 , Edward James Johns 5
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1 Analytical Biochemistry Research Centre (ABrC), Universiti Innovation Incubator Building, SAINS@USM Campus, Universiti Sains Malaysia, Lebuh Bukit Jambul 11900, Penang, MALAYSIA2 College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin, SAUDI ARABIA3 Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MALAYSIA4 Center for Drug Research, Universiti Sains Malaysia, Penang, MALAYSIA5 Department of Physiology, School of Medicine, University College of Cork, Cork, IRELAND* Corresponding Author

Abstract

Dysregulation of lipid homeostasis contributes to obesity and can directly lead to several critical public health concerns globally. This paper aimed to present a brief review of related properties and the use of pancreatic lipase inhibitors as the future weight loss drug discovery and development procured from a wide range of natural sources. A total of 176 pancreatic lipase inhibitory peptides were identified from recent publications and peptide databases. These peptides were classified into three categories according to their peptide length and further analyzed using bioinformatic approaches to identify their structural activity relationship. Molecular docking analyses were conducted for each amino acid at the terminal position of the peptides to predict the binding affinity between peptide-enzyme protein complexes based on intermolecular contact interactions. Overall, the observations revealed the features of the inhibitory peptides and their inhibitory mechanisms and interactions. These findings strived to benefit scientists whose research may be relevant to anti-obesity drug development and/or discovery thereby support effective translation of preclinical research for humans’ health being.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review Article

ELECTRON J GEN MED, Volume 20, Issue 3, June 2023, Article No: em470

https://doi.org/10.29333/ejgm/12943

Publication date: 01 May 2023

Online publication date: 07 Feb 2023

Article Views: 2029

Article Downloads: 1286

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