Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: A literature review
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Maykon Jhuly Martins de Paiva 1 2 * , Guilherme Nobre L do Nascimento 3 , Iangla Araújo de Melo Damasceno 1 , Lucas Nordhoff Barcelos Cunha 2 , Jeremias Emanoel de Sousa Pimentel 2 , Leda Terezinha Freitas e Silva 4 , Tayslane Dias Castro 3 , Dâmaris Silveira 1
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1 Laboratory of Natural Products, Faculty of Health Sciences, University of Brasília, Brasília, BRAZIL2 University of Gurupi, Paraíso do Tocantins, BRAZIL3 Laboratory of Basic and Health Sciences, Federal University of Tocantins, Palmas, BRAZIL4 Faculdade de Palmas, Palmas, BRAZIL* Corresponding Author

Abstract

Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration-dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review Article

ELECTRON J GEN MED, Volume 21, Issue 1, February 2024, Article No: em562

https://doi.org/10.29333/ejgm/14040

Publication date: 01 Jan 2024

Online publication date: 19 Dec 2023

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