Corrected QT interval and QT dispersion in temporal lobe epilepsy in children and adolescent
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Amr Hemeda Mustafa 1 , Mahmoud Mohammed Mahmoud Saber 1 , Hosny Abdel Kareem Ahmed Mahmoud 2 , Mostafa Abd Elazeem Hassan Ahamed 2 , Ahmed Hagag Ismail Ahmed 2 , Mohammed Fawzy Fouad 2 , Ahmed Mohammed Farid EL-Moazen 2 , Abd El-Monem M Hassan 2 , Ahmed Ibrahim Mostafa 1 , Ahmed Abady Ahmed Ali 1 , Ahmed Ali Faheem Abdo 3 , Al-Hussein Mustafa Zahran 3 , Alsayed Ali Almarghany 3 , Moustafa Mohamed Eldeib 3 , Abdelhamid Ismail Abdelhamid Abu Rahhal 3 , Ahmed Saadeldeen Ibrahem Mansour 1 , Ashraf Yahia Abdel Elgawad 1 , Ali Elsayed Ali Elagamy 1 , El Sayed Hamed Fahmy 1 , Khalid A Rashed 1 , Ehab Ibrahim Sorour 1 *
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1 Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, EGYPT2 Department of Pediatrics and Neonatology, Faculty of Medicine, Al-Azhar University-Assiut, Al Wilidiyyah, EGYPT3 Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGYPT* Corresponding Author

Abstract

Aim: The purpose of this research was to contrast (heart-rate corrected QT interval) QTc, and (QT dispersion) QTd intervals in individuals with (temporal lobe epilepsy) TLE and those without TLE using a standard 12-lead electrocardiogram.
Patients & methods: This cross-sectional research was undertaken on 100 cases aged 10 to 20 diagnosed with epilepsy in accordance with 2017 ILAE criteria. The patients’ informed written permission was acquired. In our study, we included 100 cases: 50 with TLE and 50 with non-TLE verified by seizure semiology. All patients were subjected to a comprehensive history, clinical examination (heart rate, pulse, and blood pressure), and clinical evaluation, which included a comprehensive epilepsy history. On the basis of neurology service documents or the initial publication of the international classification of diseases, 9th revision (ICD9) diagnostic or 10th revision (ICD10) codes for epilepsy, diagnostic age for epilepsy was calculated.
Results: The mean QT interval in group I was 418.30±25.48 ms while that of group II was 406.20±27.63 ms, the mean QTc of group I was 513.60±61.94 ms and was 488.70±50.65 in group II. The calculated QTd was with a mean of 57.60±25.05 ms while that of group II was 43.60±31.89 ms. It means that the QT interval, QTc, and QTd values were considerably greater in the group I (temporal epilepsy) contrasted with group II (non-temporal epilepsy); (p=0.025, 0.030, and 0.016, respectively). The mean QT, QTc, and QTd values for FE were 409.20±20.80, 500.70±55.60, and 52.60±29.70 ms, respectively. QT, QTc, and QTd mean values for patients with widespread epilepsy were 412.00±25.60, 505.00±68.60, and 46.20±28.70 ms. QT, QTc, and QTd interval were insignificantly different between focal and generalized epilepsy. The longer an illness progresses, the longer the QT and QTc intervals, as there was a substantial positive correlation among illness’s course and QT interval (r=0.391, p<0.001) and QTc interval (r=0.289, p=0.011), but there was no noticeable impact on QTd due to the illness’s duration, as we found an insignificant correlation among duration of illness and QTC and QTd.
Conclusions: Our findings indicate that; QTc interval and QTd are longer in epilepsy cases more among TLE cases contrasted with non-TLE. Since there was no distinction among different epilepsy types (focal and generalized).

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 21, Issue 4, August 2024, Article No: em598

https://doi.org/10.29333/ejgm/14787

Publication date: 09 Jul 2024

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