Evaluation of Three Models of Follow-up of Patients with Cervical Cytological Abnormalities in a Peruvian’s Largest Teaching Women’s Hospital
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Jeel Moya-Salazar 1 2 3 * , Jennifer Huarcaya 2 , Víctor Rojas-Zumaran 2 , Diana L. Vásquez 4 , Karina Chicoma-Flores 3 , Hans Contreras-Pulache 1 5
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1 School of Medicine, Faculties of Health Science, Universidad Privada Norbert Wiener, Lima, PERU2 Department of Pathology, Hospital Nacional Docente Madre Niño San Bartolomé, Lima, PERU3 Oncology Unit, NESH Hubbs, Lima, PERU4 Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Lima, PERU5 South America Center for Education and Research in Public Health, Universidad Norbert Wiener, Lima, PERU* Corresponding Author

Abstract

Introduction: The follow-up of squamous intraepithelial lesions (SIL) allows us to understand their progression and regression, however squamous cell atypia (ASC) can generate confusing follow-up results. We aimed to describe the evolution of ASC and SIL during cyto-histopathological follow-up in a tertiary-care hospital.
Materials and methods: we conducted a retrospective study during 2016 in 156 Papanicolaou test (PAP) results under three models: 1) with ≥1 PAP and biopsies, 2) 1 PAP followed by ≥1 biopsy, and 3) ≥1 PAP and a confirmatory biopsy. Progression was defined as ASCUS to low-grade SIL (LSIL) or higher, and LSIL to high-grade SIL (HSIL) or higher; and regression as HSIL to LSIL or lower; and LSIL to ASCUS or lower.
Results: In PAP, 57 (36.5%) cases were ASC and in histopathology 56 (39.9%) cases of grade 1 cervical intraepithelial neoplasia. Twenty-nine (18.6%) results were followed: 8 (27.6%), 17 (58.6%), and 4 (13.8%) with models 1, 2, and 3, respectively. The progression of the lesions was reported in ~50% for models 2 and 3. ASCUS was the main cytological finding that indicated biopsies, and for all models, the mean progression and regression time was 4 and 3.1 months, respectively.
Conclusions: The follow-up of cytological alterations in three models showed progression of lesions in half of the cases analyzed with a time of four months of evolution; ASCUS was the main finding that indicated histopathological study.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 19, Issue 2, April 2022, Article No: em347

https://doi.org/10.29333/ejgm/11546

Publication date: 13 Jan 2022

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