Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study

Nasrulla Shanazarov; Valery Benberin; Sergey Zinchenko; Fatima Nalgieva; Niyaz Muratov; Bakitzhan Isahanova; Tokhirzhan Tashpulatov

doi:10.29333/ejgm/11580

Nasrulla Shanazarov ¹ ^* , Valery Benberin ¹ , Sergey Zinchenko ² , Fatima Nalgieva ³ , Niyaz Muratov ² , Bakitzhan Isahanova ¹ , Tokhirzhan Tashpulatov ¹

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¹ Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, KAZAKHSTAN² Kazan Federal University, Kazan, RUSSIA³ Multidisciplinary Medical Center, Nur-Sultan, KAZAKHSTAN^* Corresponding Author

Abstract

This article presents a clinical observation of successful treatment of a patient with multiple cylindroma of the scalp and trunk using photodynamic therapy (PDT) after radiotherapy. The first masses were found in 2008, at the same time they were surgically removed. There has been a progression of the process since 2019 - multiple masses on the scalp and trunk. There was another visit to doctors. After verification of diagnosis radiation therapy was received. However, soon after the treatment, the appearance of new and growth of existing foci has been noted. A multistage PDT with good clinical and cosmetic effect was carried out at Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan.

Keywords

cylindroma
radiation therapy
photodynamic therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

ELECTRON J GEN MED, Volume 19, Issue 2, April 2022, Article No: em359

https://doi.org/10.29333/ejgm/11580

Publication date: 20 Jan 2022

Article Views: 1351

Article Downloads: 1596

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References

Sellheyer K. Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gand: An immunohistochemical study with CD200 and other stem cell markers. J Cutan Pathol. 2015;42(2):90-101. https://doi.org/10.1111/cup.12406 PMid:25354097
Calonje E. Tumours of the skin appendages. In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s textbook of dermatology. Singapore: Wiley-Blackwell; 2010. p. 28-53. https://doi.org/10.1002/9781444317633.ch53 PMid:20055901
Rajan N, Ashworth A. Inherited cylindromas: Lessons from a rare tumour. Lancet Oncol. 2015;16(9):e460-e9. https://doi.org/10.1016/S1470-2045(15)00245-4 PMid:26370355
Saga K. Histochemical and immunohistochemical markers for human eccrine and apocrine sweat glands: An aid for histopathologic differentiation of sweat gland tumors. J Investig Dermatol Symp Proc. 2001;6(1):49-53. https://doi.org/10.1046/j.0022-202x.2001.00005.x PMid:11764285
Blake PW, Toro JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: Novel insights into the role of deubiquitination in cell signaling. Hum Mutat. 2009;30(7):1025-36. https://doi.org/10.1002/humu.21024 PMid:19462465 PMCid:PMC3243308
Bowen S, Gill M, Lee DA, et al. Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: Lack of genotype-phenotype correlation. J Invest Dermatol. 2005;124(5):919-20. https://doi.org/10.1111/j.0022-202X.2005.23688.x PMid:15854031
Tauriello DVF, Haegebarth A, Kuper I, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37(5):607-19. https://doi.org/10.1016/j.molcel.2010.01.035 PMid:20227366
Sun S-C. CYLD: A tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010;17(1):25-34. https://doi.org/10.1038/cdd.2009.43 PMid:19373246 PMCid:PMC5848464
Durani BK, Kurzen H, Jaeckel A, Kuner N, Naeher H, Hartschuh W. Malignant transformation of multiple dermal cylindromas. Br J Dermatol. 2001;145(4):653-6. https://doi.org/10.1046/j.1365-2133.2001.04460.x PMid:11703297
Weedon D. Tumors of cutaneous appendages. In: Weedon D, ed. Weedon’s skin pathology. China: Elsevier; 2010:785-6. https://doi.org/10.1016/b978-0-7020-3485-5.00034-6
Bignell GR, Warren W, Seal S, et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 2000;25(2):160-5. https://doi.org/10.1038/76006 PMid:10835629
Massoumi R. CYLD: A deubiquitination enzyme with multiple roles in cancer. Future Oncol. 2011;7(2):285-97. https://doi.org/10.2217/fon.10.187 PMid:21345146
Canedo T, de Almeida MP, Cuzzi T, Ramos-e-Silva M. Immunophenotypic aspects of cylindroma and nodular hidradenoma. J Eur Acad Dermatol Venereol. 2010;24(2):178-85. https://doi.org/10.1111/j.1468-3083.2009.03398.x PMid:19796089
Cotton DW, Braye SG. Dermal cylindromas originate from the eccrine sweat gland. Br J Dermatol. 1984;111(1):53-61. https://doi.org/10.1111/j.1365-2133.1984.tb04016.x PMid:6331489
Missall TA, Burkemper NM, Jensen SL, Hurley MY. Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol. 2009;36(2):190-6. https://doi.org/10.1111/j.1600-0560.2008.00991.x PMid:18564284
Penneys NS, Kaiser M. Cylindroma expresses immunohistochemical markers linking it to eccrine coil. J Cutan Pathol. 1993;20(1):40-3. https://doi.org/10.1111/j.1600-0560.1993.tb01247.x PMid:7682227
Hashimoto K, Lever WF. Histogenesis of skin appendage tumors. Arch Dermatol. 1969;100(3):356-69. https://doi.org/10.1001/archderm.1969.01610270098021 PMid:4309779
Layegh P, Sharifi-Sistani N, Abadian M, Moghiman T. Brooke-Spiegler syndrome. Indian J Dermatol Venereol Leprol. 2008;74:632-4. https://doi.org/10.4103/0378-6323.45109 PMid:19171990
Bilyalov AI, Shanazarov NA, Zinchenko SV. Photodynamic therapy as alternative method of treatment of metastatic ovarian cancer with many recurrence: Case report. CA Cancer J Clin. 2011;61(4):250-81. https://doi.org/10.1007/s12668-020-00749-7 PMid:21617154 PMCid:PMC3209659
Oosterkamp HM, Neering H, Nijman SM, et al. An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. Br J Dermatol. 2006;155(1):182-5. https://doi.org/10.1111/j.1365-2133.2006.07224.x PMid:16792771
Brass D, Rajan N, Langtry J. Enucleation of cylindromas in Brooke-Spiegler syndrome: A novel surgical technique. Dermatol Surg. 2014;40(12):1438-9. https://doi.org/10.1097/DSS.0000000000000142 PMid:25361203 PMCid:PMC6082342
Massoumi R, Podda M, Fassler R, Paus R. Cylindroma as tumor of hair follicle origin. J Invest Dermatol. 2006;126(5):1182-4. https://doi.org/10.1038/sj.jid.5700218 PMid:16484982
Rajan N, Andersson M, Sinclair A, et al. Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells. J Pathol. 2016;239(2):197-205. https://doi.org/10.1002/path.4717 PMid:26969893 PMCid:PMC4869681
Richard A, Chevalier JM, Verneuil L, et al. CO2 laser treatment of skin cylindromas in Brooke-Spiegler syndrome. Dermatol Surg. 2000;26(9):877-80; discussion 881. https://doi.org/10.1046/j.1524-4725.2000.00034.x PMid:10971563
Rajan N, Trainer AH, Burn J, Langtry JA. Familial cylindromatosis and Brooke-Spiegler syndrome: A review of current therapeutic approaches and the surgical challenges posed by two affected families. Dermatol Surg. 2009;35(5):845-52. https://doi.org/10.1111/j.1524-4725.2009.01142.x PMid:19397670
Aguilera CA, de la Varga R, García LO, Jiménez D, Planelles CA, Barrios ML. Heterozygous cylindromatosis gene mutation c.1628_1629delct in a family with Brook-Spiegler syndrome. Indian J Dermatol. 2016;61(5):580. https://doi.org/10.4103/0019-5154.190130 PMid:27688459 PMCid:PMC5029256
Dhua S, Sekhar DR. A rare case of eccrine spiradenoma-treatment and management. Eur J Plast Surg. 2016;39:143-6. https://doi.org/10.1007/s00238-015-1103-4 PMid:27069311 PMCid:PMC4803810
Ankad BS, Beergouder SL, Domble V, Sujana L. A serpentine inside eccrine spiradenoma: A new trichoscopic sign. Int J Trichology. 2015;7(1):38-40. https://doi.org/10.4103/0974-7753.153460 PMid:25878450 PMCid:PMC4387699
Yen TTH, Ramenskaya GV, Oborotova NA. Chlorin derivatives in cancer photodynamic therapy. Russian J Biotherapy. 2009;4:99-101.
Rajan N, Langtry JA, Ashworth A, Roberts C. Familial cylindromatosis and Brooke-Spiegler syndrome: A review of current therapeutic approaches and the surgical challenges posed by two affected families. Dermatol Surg. 2009;35(5):845-52. https://doi.org/10.1111/j.1524-4725.2009.01142.x PMid:19397670
Jordão C, de Magalhães TC, Cuzzi T, Ramos-e-Silva M. Cylindroma: An update. Int J Dermatol. 2015;54(3):275-8. https://doi.org/10.1111/ijd.12600 PMid:25515269
Lallas A, Apalla Z, Tzellos T, Lefaki I. Dermoscopy of solitary cylindroma. Eur J Dermatol. 2011;21(4):645-6. https://doi.org/10.1684/ejd.2011.1413 PMid:21697054
Shanazarov N, Zinchenko S, Zhapparov E, et al. The clinical case of successful application of photodynamic therapy in the skin metastases treatment of breast cancer. BioNanoScience. 2021;11:957-61. https://doi.org/10.1007/s12668-021-00907-5

How to cite this article

Vancouver

Shanazarov N, Benberin V, Zinchenko S, Nalgieva F, Muratov N, Isahanova B, et al. Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study. ELECTRON J GEN MED. 2022;19(2):em359. https://doi.org/10.29333/ejgm/11580

APA

Shanazarov, N., Benberin, V., Zinchenko, S., Nalgieva, F., Muratov, N., Isahanova, B., & Tashpulatov, T. (2022). Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study. Electronic Journal of General Medicine, 19(2), em359. https://doi.org/10.29333/ejgm/11580

AMA

Shanazarov N, Benberin V, Zinchenko S, et al. Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study. ELECTRON J GEN MED. 2022;19(2), em359. https://doi.org/10.29333/ejgm/11580

Chicago

Shanazarov, Nasrulla, Valery Benberin, Sergey Zinchenko, Fatima Nalgieva, Niyaz Muratov, Bakitzhan Isahanova, and Tokhirzhan Tashpulatov. "Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study". Electronic Journal of General Medicine 2022 19 no. 2 (2022): em359. https://doi.org/10.29333/ejgm/11580

Harvard

Shanazarov, N., Benberin, V., Zinchenko, S., Nalgieva, F., Muratov, N., Isahanova, B., and Tashpulatov, T. (2022). Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study. Electronic Journal of General Medicine, 19(2), em359. https://doi.org/10.29333/ejgm/11580

MLA

Shanazarov, Nasrulla et al. "Possibilities of Photodynamic Therapy in the Treatment of Multiple Cylindroma of the Scalp: The Clinical Case Study". Electronic Journal of General Medicine, vol. 19, no. 2, 2022, em359. https://doi.org/10.29333/ejgm/11580