Role of HGF polymorphisms in the development of keratoconus in South Asian population
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Farhan Khashim Alswailmi 1 *
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1 Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin, SAUDI ARABIA* Corresponding Author

Abstract

Background: Hepatocyte growth factor (HGF) has been previously reported to be causative of keratoconus (KC) in different populations.
Aims: The current study was conducted to investigate the role of HGF single nucleotide polymorphisms (SNPs) in sporadic KC cases from South Asian population of Pakistani origin.
Methodology: A total of 100 sporadic cases were screened KC associated reported polymorphisms in HGF (rs17501108 and rs3735520) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: No significant association of the HGF SNPs were observed in the sporadic cases of KC and possibility of involvement of another gene in the pathogenesis of KC exist.
Conclusion: Present study came with the findings that although globally an association exit between HGF and KC but genotyping data of Asian population of Pakistan origin does not show any association between HGF and pathogenesis of KC.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 20, Issue 1, February 2023, Article No: em439

https://doi.org/10.29333/ejgm/12700

Publication date: 01 Jan 2023

Online publication date: 10 Dec 2022

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