Serum Level of Soluble Vascular Adhesion Molecule 1 in Patients with Rectal Cancer
Özgür Kemik 1 * , Ahu Sarbay Kemik 2, İsmail Hasırcı 1, Mine Adaş 3, Sevim Purisa 2, Ahmet Cumhur Dülger 1, Sefa Tüzün 4
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1 Yuzuncu Yıl University Medical Faculty, Van, Turkey2 University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey3 Okmeydanı Education and Training Hospital, Department of Endocrinology, İstanbul, Turkey4 Haseki Education and Training Hospital, II. General Surgery, İstanbul, Turkey* Corresponding Author

Abstract

Aim: Vascular adhesion molecule 1 (VCAM-1) plays an important role in solid tumor enlargement and/or metastases. This study evaluated the clinical significance of measuring serum levels of soluble VCAM-1 in rectal cancer and aimed to clarify the biologic significance of its local expression. Method: Serum was collected from 90 patients with rectal cancer and 40 healthy volunteers. Cancer tissue was collected from 84 patients. The level of soluble VCAM-1 in serum and cancer tissue was measured enzyme linked immunosorbent assay. Result: The mean soluble VCAM-1 level in patients was significantly higher than that in control subjects. Elevated serum soluble VCAM-1 was significantly associated with clinicopathologic paramaters such as tumor size, lymph node metastasis, distant metastasis, and poor prognosis. The prognosis for stage 2 patients positive for soluble VCAM-1 level was comparable to that for stage 3 patients. In addition, the serum level of soluble VCAM-1 level was not found correlation with the cancer tissue level. Conclusion: The preoperative level of soluble VCAM-1 level reflected disease progression and was a sensitive biomarker for rectal cancer.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, Volume 8, Issue 2, April 2011, 105-109

https://doi.org/10.29333/ejgm/82709

Publication date: 11 Apr 2011

Article Views: 1150

Article Downloads: 803

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