Serum Lipid Profile and Inflammatory Status in Women with Gestational Diabetes Mellitus
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Ebru Yorulmaz Ertuğ 1, Murat Usta 2 * , Özlem Baytekin 3, Vesile Örnek Diker 4, Engin Korkmazer 5, Enis Özkaya 6
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1 Cerkezkoy Government Hospital, Department of Medical Biochemistry, Tekirdag, Turkey2 Giresun University, Medical Faculty, Department of Medical Biochemistry, Giresun, Turkey3 Arnavutkoy Government Hospital, Department of Medical Biochemistry, Istanbul, Turkey4 Mehmet Akif Ersoy Thoracic, Heart,and Vascular Surgery Research and Training Hospital, Department of Medical Biochemistry, Istanbul, Turkey5 Giresun University, Medical Faculty, Department of Obstetrics and Gynecology, Giresun, Turkey6 Dr Sami Ulus Obstetrics and Gynecology, Children's Health and Diseases Research and Training Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey* Corresponding Author

Abstract

Objective:
Gestational diabetes mellitus (GDM) is associated with increased risk of postpartum type 2 diabetes mellitus and cardiovascular risk factors such as obesity, hypertension, dyslipidemia, and systemic inflammation. We aimed to evaluate the lipid profile and inflammatory status assessed by high sensitive C-reactive protein (hsCRP) and TNF-α levels. We also evaluated insulin resistance for all participants.

Methods:
This study was performed including the pregnant with normal glucose challenge test (GCT) and normal glucose tolerance (NGT) (n:20), abnormal GCT and NGT (n:27), and GDM (n:29) defined by Carpenter and Coustan criteria.

Results:
In our study, we could not find significantly differences by means of hsCRP levels and lipid profile parameters between groups. But, TNF-α levels increased significantly in the GDM or abnormal GCT NGT groups as compared to the normal GCT NGT group. hsCRP was correlated independently with LDL-cholesterol and parity in the abnormal GCT NGT group and atherogenic index of the plasma (AIP) in GDM group. In addition, there was not an independent relationship between AIP and hsCRP in the GDM group when multiple linear regression analysis was performed after adjustment for maternal age was evaluated at 29.49 years.

Conclusion:
In conclusion, gestational insulin resistance was apparently associated with TNF-α, whereas dyslipidemia was slightly associated with hsCRP because of the possible effects of maternal age on lipid markers.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, Volume 13, Issue 1, January 2016, 45-52

https://doi.org/10.15197/ejgm.01471

Publication date: 16 Jan 2016

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Article Downloads: 1003

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