The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2

Amira Hasnanuha Ulayya; Ahmad Zaki Mubarok; Widodo Widodo; Simon Bambang Widjanarko; Marlita Marlita

doi:10.29333/ejgm/11402

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Amira Hasnanuha Ulayya ¹ ^* , Ahmad Zaki Mubarok ¹, Widodo Widodo ² ^* , Simon Bambang Widjanarko ¹, Marlita Marlita ²

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¹ Faculty of Agricultural Technology, Universitas Brawijaya, INDONESIA² Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, INDONESIA^* Corresponding Author

Abstract

The inhibition of SARS-Cov-2 S binding with hACE2, expressed in most human tissues, may prevent the severity of virus infection. However, commercial ACE2 inhibitor drugs are still limited, while several natural compounds have already been reported to have anti-ACE2 activity. We found the potential of hydrolyzed glucomannan of porang tuber in the inhabitation of binding activity between ACE2 and S1 of SARS-Cov-2.

Keywords

ACE2
SARS-Cov-2
S1
glucomannan
porang

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Short Communication

ELECTRON J GEN MED, Volume 19, Issue 1, February 2022, Article No: em340

https://doi.org/10.29333/ejgm/11402

Publication date: 02 Dec 2021

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How to cite this article

Vancouver

Ulayya AH, Mubarok AZ, Widodo W, Widjanarko SB, Marlita M. The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2. ELECTRON J GEN MED. 2022;19(1):em340. https://doi.org/10.29333/ejgm/11402

APA

Ulayya, A. H., Mubarok, A. Z., Widodo, W., Widjanarko, S. B., & Marlita, M. (2022). The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2. Electronic Journal of General Medicine, 19(1), em340. https://doi.org/10.29333/ejgm/11402

AMA

Ulayya AH, Mubarok AZ, Widodo W, Widjanarko SB, Marlita M. The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2. ELECTRON J GEN MED. 2022;19(1), em340. https://doi.org/10.29333/ejgm/11402

Chicago

Ulayya, Amira Hasnanuha, Ahmad Zaki Mubarok, Widodo Widodo, Simon Bambang Widjanarko, and Marlita Marlita. "The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2". Electronic Journal of General Medicine 2022 19 no. 1 (2022): em340. https://doi.org/10.29333/ejgm/11402

Harvard

Ulayya, A. H., Mubarok, A. Z., Widodo, W., Widjanarko, S. B., and Marlita, M. (2022). The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2. Electronic Journal of General Medicine, 19(1), em340. https://doi.org/10.29333/ejgm/11402

MLA

Ulayya, Amira Hasnanuha et al. "The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2". Electronic Journal of General Medicine, vol. 19, no. 1, 2022, em340. https://doi.org/10.29333/ejgm/11402