The interaction of glutathione and thymoquinone and their antioxidant properties

Ferah Armutcu; Sumeyya Akyol; Omer Akyol

doi:10.29333/ejgm/89493

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Ferah Armutcu ¹ ^* , Sumeyya Akyol ², Omer Akyol ³

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¹ Professor of Medical Biochemistry, Private Esencan Hospital Esenyurt, Istanbul, Turkey² Associate Professor of Medical Biochemistry, 225 Fluor Daniel Dr., Houston, TX 77479, USA³ Professor of Medical Biochemistry, 225 Fluor Daniel Dr., Houston, TX 77479, USA^* Corresponding Author

Abstract

Protein S-glutathionylation has been regarded as one of the main mechanisms that control cell signaling and metabolic regulation. Several diseases including cardiovascular diseases, diabetes, neurodegenerative diseases and many types of cancer have been certainly found to be related with S-glutathionylation. It can be regarded as a promising area for therapeutic and diagnostic approaches in many diseases. In this mini review, we aimed to summarize and compare the interaction of glutathione (GSH) and thymoquinone (TQ), and elucidate the possible synergistic mechanisms of antioxidant and other beneficial effects.

Keywords

glutathione
glutathionylation
thymoquinone
Oxidative Stress

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review Article

ELECTRON J GEN MED, Volume 15, Issue 4, August 2018, Article No: em59

https://doi.org/10.29333/ejgm/89493

Publication date: 15 Apr 2018

Article Views: 2917

Article Downloads: 3408

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Declaration of Conflict of Interest: No conflict of interest is declared by author(s).

References

Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 2003;66(8):1499-503. https://doi.org/10.1016/S0006-2952(03)00504-5.
Ribas V, García-Ruiz C, Fernández-Checa JC. Glutathione and mitochondria. Front Pharmacol 2014;5:151. https://doi.org/10.3389/fphar.2014.00151.
Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology 2005;49(4):456-64. https://doi.org/10.1016/j.neuropharm.2005.04.004.
Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 2003;26(2):87-98. https://doi.org/10.1081/DCT-120020404.
Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol 2012;83(4):443-51. https://doi.org/10.1016/j.bcp.2011.09.029.
Diaz-Vivancos P, de Simone A, Kiddle G, Foyer CH. Glutathione-linking cell proliferation to oxidative stress. Free Radic Biol Med 2015;89:1154-64. https://doi.org/10.1016/j.freeradbiomed.2015.09.023.
Pimentel D, Haeussler DJ, Matsui R, Burgoyne JR, Cohen RA, Bachschmid MM. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal. 2012;16(6):524-42. https://doi.org/10.1089/ars.2011.4336.
Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 2003;57:145-55. https://doi.org/10.1016/S0753-3322(03)00043-X.
Xiong Y, Uys JD, Tew KD, Townsend DM. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal 2011;15(1):233-70. https://doi.org/10.1089/ars.2010.3540.
Oter O, Jin S, Cucullo L Damien Dorman HJ. Oxidants and antioxidants: friends or foes? Oxid Antioxid Med Sci 2012;1(1):1-4. https://doi.org/10.5455/oams.080612.ed.001.
Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD. Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013;288(37):26497-504. https://doi.org/10.1074/jbc.R113.461368.
Ullevig SL, Kim HS, Short JD, Tavakoli S, Weintraub ST, Downs K, Asmis R. Protein S-glutathionylation mediates macrophage responses to metabolic cues from the extracellular environment. Antioxid Redox Signal 2016;25(15):836-51. https://doi.org/10.1089/ars.2015.6531.
Dalle-Donne I, Milzani A, Gagliano N, Colombo R, Giustarini D, Rossi R. Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid Redox Signal 2008;10(3):445-473. https://doi.org/10.1089/ars.2007.1716.
Ghezzi P. Protein glutathionylation in health and disease. Biochim Biophys Acta 2013;1830(5):3165-72. https://doi.org/10.1016/j.bbagen.2013.02.009.
Schneider-Stock R, Fakhoury IH, Zaki AM, El-Baba CO, Gali-Muhtasib HU. Thymoquinone: fifty years of success in the battle against cancer models. Drug Discov Today 2014;19(1):18-30. https://doi.org/10.1016/j.drudis.2013.08.021.
Sanchez-Gomez FJ, Espinosa-Diez C, Dubey M, Dikshit M, Lamas S. S-glutathionylation: relevance in diabetes and potential role as a biomarker. Biol Chem 2013;394(10):1263-80. https://doi.org/10.1515/hsz-2013-0150.
Pastore A, Piemonte F. Protein glutathionylation in cardiovascular diseases. Int J Mol Sci 2013; 14(10):20845-76. https://doi.org/10.3390/ijms141020845.
Cooper AJ, Pimto JT, Callery PS. Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol 2011;7(7):891-910. https://doi.org/10.1517/17425255.2011.577738.
Cha SJ, Kim H, Choi HJ, Lee S, Kim K. Protein glutathionylation in the pathogenesis of neurodegenerative diseases. Oxid Med Cell Longev 2017. https://doi.org/10.1155/2017/2818565.
Garrett T, Tew KD, and Townsend DM. Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother 2010;64(1):73-6. https://doi.org/10.1016/j.biopha.2009.09.009.
Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacol Res 2015;95-96:138-58. https://doi.org/10.1016/j.phrs.2015.03.011.
Khalife KH, Lupidi G. Nonenzymatic reduction of thymoquinone in physiological conditions. Free Radic Res 2007;41(2):153-61. https://doi.org/10.1080/10715760600978815.
Khalife KH, Lupidi G. Reduction of hypervalent states of myoglobin and hemoglobin to their ferrous forms by thymoquinone: the role of GSH, NADH and NADPH. Biochim Biophys Acta 2008;1780(4):627-37. https://doi.org/10.1016/j.bbagen.2007.12.006.
Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer 2010(7);62:938-946. https://doi.org/10.1080/01635581.2010.509832.
Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol 2010;83(4):443-51. https://doi.org/10.1016/j.bcp.2011.09.029.
Arslan SO, Gelir E, Armutcu F, Coskun O, Gurel A, Sayan H, Celik IL. The protective effect of thymoquinone on ethanol-induced acute gastric damage in the rat. Nutr Res 2005;25(7):673-80. https://doi.org/10.1016/j.nutres.2005.06.004.
Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci 2001;98(6):3404-9. https://doi.org/10.1073/pnas.051632198.
Kundu J, Chun KS, Aruoma OI, Kundu JK. Mechanistic perspectives on cancer chemo-prevention/chemotherapeutic effects of thymoquinone. Mutat Res 2014;768:22-34. https://doi.org/10.1016/j.mrfmmm.2014.05.003.
Sankaranarayanan C, Pari L. Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats. Chem Biol Interact 2011;190(2-3):148-54. https://doi.org/10.1016/j.cbi.2011.02.029.
Sayed-Ahmed MM, Nagi MN. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 2007;34(5-6):399-405. https://doi.org/10.1111/j.1440-1681.2007.04560.x.
Nagi MN, Almakki HA. Thymoquinone Supplementation induces quinone reductase and glutathione transferase in mice liver: Possible role in protection against chemical carcinogenesis and toxicity. Phytother Res 2009;23(9):1295-8. https://doi.org/10.1002/ptr.2766.
Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 2002;20(2):143-51. https://doi.org/10.1002/cbf.968.
Sayed-Ahmed MM, Aleisa AM, Al-Rejaie SS, Al-Yahya AA, Al-Shabanah OA, Hafez MM, Nagi MN. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxid Med Cell Longev 2010;3(4):254-61. https://doi.org/10.4161/oxim.3.4.12714.
Goyal SN, Prajapati CP, Gore PR, Patil CR, Mahajan UB, Sharma C, Talla SP, Ojha SK. Therapeutic potential and pharmaceutical development of thymoquinone: A multitargeted molecule of natural origin. Front Pharmacol 2017;8:656. https://doi.org/10.3389/fphar.2017.00656.

How to cite this article

Vancouver

Armutcu F, Akyol S, Akyol O. The interaction of glutathione and thymoquinone and their antioxidant properties. ELECTRON J GEN MED. 2018;15(4):em59. https://doi.org/10.29333/ejgm/89493

APA

Armutcu, F., Akyol, S., & Akyol, O. (2018). The interaction of glutathione and thymoquinone and their antioxidant properties. Electronic Journal of General Medicine, 15(4), em59. https://doi.org/10.29333/ejgm/89493

AMA

Armutcu F, Akyol S, Akyol O. The interaction of glutathione and thymoquinone and their antioxidant properties. ELECTRON J GEN MED. 2018;15(4), em59. https://doi.org/10.29333/ejgm/89493

Chicago

Armutcu, Ferah, Sumeyya Akyol, and Omer Akyol. "The interaction of glutathione and thymoquinone and their antioxidant properties". Electronic Journal of General Medicine 2018 15 no. 4 (2018): em59. https://doi.org/10.29333/ejgm/89493

Harvard

Armutcu, F., Akyol, S., and Akyol, O. (2018). The interaction of glutathione and thymoquinone and their antioxidant properties. Electronic Journal of General Medicine, 15(4), em59. https://doi.org/10.29333/ejgm/89493

MLA

Armutcu, Ferah et al. "The interaction of glutathione and thymoquinone and their antioxidant properties". Electronic Journal of General Medicine, vol. 15, no. 4, 2018, em59. https://doi.org/10.29333/ejgm/89493